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KMID : 0370219880320030157
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Yakhak Hoeji
1988 Volume.32 No. 3 p.157 ~ p.163
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Synthesis and Cardiovascular Activities of 1, 4-Dihydropyridine Derivatives
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Shim Young-Key
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Abstract
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4-Aryl-1, 4-dihydropyridines(DHP) derived from Hantsch type condensation of aromatic aldehydes with aminocrotonates and acetoacetic esters are studied as calcium channel blocking drugs. New DHP derivatives containing alkenyl ester show fairly good cardiovascular activity in mice. Preparation of the DHP derivatives and their major biological activity are presented along with their physical data.
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